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Clinical studies on skin health indicate potential effects on melanin index and skin brightness with sustained use [13] [14]

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Journal of Immunology

Gallogly S, Fujisawa T, Hung JD, Brittan M, Skinner EM, Mitchell AJ, Medine C, Luque N, Zodda E, Cascante M, Hadoke PW, Mills NL, Tura-Ceide O (2021) Generation of a novel in vitro model to study endothelial dysfunction from atherothrombotic specimens

This stimulates the sympathetic nervous system, which leads to the secretion of adrenaline by the adrenal marrow and ACTH by the hypothalamus so that more cortisol is secreted

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