how to give yourself a b12 injection in the thigh Use These 4 IM Spots Safely How to Give B12 Injections

The Pernicious Anaemia Society notes this is well recognised but not fully understood

Nervous System Maintenance : It keeps the nervous system healthy by making myelin, a fatty substance

Pyridoxine (B) is notably used during pregnancy to treat nausea and vomiting

IV administration gives the vitamin directly into the blood, which is critical in some situations

A good starting dose would be 500mcg (0.5mg) per day, but you can give up to twice as much

Sensory Symptoms Numbness, tingling, or pins and needles (paresthesia) typically distal/stocking-glove in polyneuropathy Burning pain, allodynia, hyperalgesia common in small-fiber predominant neuropathy and CIDP Loss of proprioception and vibration sense sensory ataxia, positive Romberg sign Loss of pain/temperature sensation (small fiber) risk of unnoticed wounds Motor Symptoms Distal muscle weakness (foot drop in peroneal neuropathy, wrist drop in radial neuropathy) Atrophy of intrinsic hand muscles (ulnar/median neuropathy) Hyporeflexia or areflexia (ankle jerks lost early in length-dependent polyneuropathy) Fasciculations in severe axonal loss Autonomic Symptoms Orthostatic hypotension, dizziness on standing Gastroparesis, constipation or diarrhea, nausea Neurogenic bladder (hesitancy, retention, incontinence) Anhidrosis or gustatory sweating Sexual dysfunction