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Apply a broad-spectrum SPF 50 sunscreen every morning and reapply every 2 to 3 hours outdoors
However, other topical depigmenting agents including niacinamide, azelaic acid, 4-n-butylresorcinol, kojic acid, resveratrol and ascorbic acid are considered in melasma management
In the future, the following points are worthy of attention
Certificate of Analysis (COA) Documentation from laboratory testing showing peptide purity, typically via HPLC-MS methods
If standardized peptide formulations can be verified and administered within controlled protocols, these agents may represent a future adjunct to evidence-based perioperative care, particularly in populations undergoing TJA where wound healing, metabolic health, and inflammatory regulation strongly influence outcomes
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