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[2] Nervous system Brain Progressive brain changes [3] Central nervous system increased ventricular lactate [4] [5] [6] [7] neuroinflammation [8] [9] [10] [11] reduced grey [12] and white matter [3] [12] widespread metabolite abnormalities [10] Autonomic nervous system Peripheral nervous system Muscular system mitochondrial abnormalities found via muscle biopsy including: mitochondrial degeneration, [15] deletions of mitochondrial DNA, [16] [17] the reduction of mitochondrial activity [16] Increased urinary creatine excretion during relapses [18] Increased creatine kinase (postviral fatigue syndrome) Persistence of enteroviruses in muscle tissue [19] [20] [21] [22] Abnormalities of AMPK activation and glucose uptake in cultured skeletal muscle cells [23] [24] Reduced serum creatine kinase in people with severe ME
Luminescence was quantified in tumor bearing limbs vs
The 500 Dalton rule (molecular weight below 500 Da correlates with percutaneous absorption) is a necessary but not sufficient condition, not a guarantee
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