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Accumulating evidence indicates that high glucose, hemodynamic changes, and local growth factors are all involved in the pathogenesis of diabetic nephropathy 6,7,8,9,10

It modulates the nitric oxide (NO) system, maintaining optimal vascular function and tissue perfusion

Your risk for getting low blood sugar may be higher if you use tirzepatide with medicines that can cause low blood sugar, such as a sulfonylurea or insulin

doi: 10.1189/jlb.0704387

However, among patients undergoing routine hemodialysis, high TMAO levels are significantly associated with higher hospitalization rates, and patients with high plasma TMAO levels have higher hospitalization rates than those with low plasma TMAO levels (Zheng et al., 2020)

They may also take your vitals and discuss any potential side effects