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Genetic defects in Indian Wilson disease patients and genotype-phenotype correlation

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Thioredoxin reductases (TXNRDs) employ NADPH as an electron donor to revert oxidized TXN to a reduced dithiol, the oxidation status of which is critically implicated in regulating various cell behaviors including proliferation and apoptosis 51

The liver takes up dietary copper from the portal blood, synthesizes cuproproteins in hepatocytes, and secretes excess copper into the bile

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Iodine and brain-targeted hormone regulation Iodine is indispensable for thyroid hormone synthesis and, through this role, exerts profound indirect effects on the brain (140)