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How to Manage Normal Post-Injection Pain Ice application: Apply ice wrapped in a towel for 15-20 minutes every few hours during the first 48 hours [3]

It should be kept in mind that although B12 injections are quite effective, they are not fairy dust

Methionine in turn is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA, RNA, and proteins ( Figure 1 ) (3)

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But does the science back that up

That said, tolerability is broadly similar across the three compounds: gastrointestinal adverse events dominate, and slow titration is the universal strategy for managing them