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In the next step, isocitrate dehydrogenase (IDH) metabolizes isocitrate to -ketoglutarate (-KG), which is further metabolized to succinyl-CoA by -KG dehydrogenase complex

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FIGURE 3 Targeting peptides protected keratinocytes against H 2 O 2 damage We tested the cytotoxicity of peptides at different concentrations on two human skin cell lines that were mainly distributed in the epidermis and dermis layers

This does not mean higher doses are beneficial, only that accidental overdose within reasonable ranges carries minimal acute risk

In the LPS-induced acute lung injury mouse model, treatment of GHK-Cu also significantly suppressed TNF- and IL-6 expression with a significant decrease of both NF-B p65 and p38 MAPK signaling, suggesting that GHK-Cu is useful for the development of novel anti-inflammatory therapies [22]