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-Synuclein has been reported to cause dysfunction of mitochondrial complex I in PD which in turn increases levels of ROS and consequently ROS-induced oxidative stress (Winklhofer and Haass 2010)

45 This essential role of GSH in immunity might explain why in many diseases, not only AIDS, decreased GSH levels are associated with an increased susceptibility to infection

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The active cleaved HGF is a heterodimer made by two disulfide bridge-linked chains, namely, the heavy and light chains ( and , respectively) (Figure 1)