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Dihexa and its analogs bind with high affinity to HGF, induce Met phosphorylation in the presence of subthreshold levels of HGF, stimulate hippocampal spinogenesis and synaptogenesis equivalent with HGF [84], and promote neurogenesis and cerebroprotection (data in preparation for publication)
Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders
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Reduce it with therapy, exercise, journaling, and socialization to ease symptoms