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doi: 10.1016/j.jep.2020.112876

Rybka J, Kupczyk D, Kdziora-Kornatowska K, Motyl J, Czuczejko J, Szewczyk-Golec K, et al

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Approximately 70% of sulfamethoxazole and 44% of trimethoprim are bound to plasma proteins

In the duodenum, pancreatic enzymes cleave B12 from R-proteins, allowing binding to intrinsic factor produced by gastric parietal cells