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Concurrently, it activates the Nrf2 pathway, promoting the transcription of antioxidant response element (ARE)dependent genes like heme oxygenase1 (HO1) and NAD(P)H quinone dehydrogenase 1 (NQO1), which enhance cellular antioxidant defenses (Balogun et al

Think of it as turning up the volume on a speaker: the signal gets stronger, but the natural rhythm remains intact

Hsieh MJ, Liu HT, Wang CN, et al

Kung L, Roberts RC

Estrogen has natural anti-inflammatory properties, so as estrogen falls, inflammation can increase

However, thicker skin may require formulations designed for body use, and results may vary depending on skin sensitivity and exposure to sun or friction