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Thus, cancer cells are under constant ER stress and to deal with these circumstances induce UPR pathways

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For example, genome-wide association studies (GWAS) have identified overlapping risk loci for AUD and MDD, including variants near DRD2 (dopamine receptor D2) and FTO (involved in oxidative stress), suggesting shared molecular pathways (Evangelia et al

Epidemiologically, full truncal vagotomy (cutting vagus connections to gut) has been associated with lower PD incidence, hinting that in some patients the gut-to-brain route is critical [33]

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