The main mechanism of platinum drugs is to hamper the replication and transcription of DNA by forming covalent adducts between platinum complexes and subcellular compounds like DNA, RNA, and other proteins (Makovec, 2019)
A 24 h time point was chosen based on a previous report of using this time period for transfecting or treating 3T3-L1 cells with NNMT anti-sense oligonucleotides or a small molecule NNMT product inhibitor (1-MNA), respectively, for phenotypic measures.[12] MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (ATCC
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Due to this limited intervention time, only about 35% of patients are eligible to receive tPA treatment (Fonarow et al., 2011) and 28% of that eligible population experience intracerebral hemorrhage as a consequence of receiving tPA (Miller et al., 2011)
