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The copper complex also decreased secretion of transforming growth factor-beta1 (TGF-beta1) by dermal fibroblasts significant because TGF-beta1 is a catagen-inducing signal that pushes follicles out of the growth phase (Pyo et al., 2007)
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Conversely, 10 proteins were downregulated, including STAM Binding Protein (STAMBP), Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2), Axin Protein 1 (AXIN1), Delta/Notch EGF Repeat-Containing (DNER), Ephrin Type-B Receptor 6 (EPHB6), Neutral Endopeptidase (NEP), Fibroblast Growth Factor 5 (FGF-5), Neuronal Cell Adhesion Molecule (Nr-CAM), Spondin 1 (SPOCK1) and S SH2 Domain Containing 1 A (SH2D1A)
Additionally, established procedures help support reliable batch-to-batch performance and standardized research material preparation