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RNR inhibition is sufficient to suppress lipid peroxide accumulation and ferroptosis To strengthen the results obtained above using pharmacological inhibitors we silenced expression of the essential RNR subunit RRM1 using siRNA

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J Biol Chem 291(53):2695026957 Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K, Kawaguchi M, Watanabe T, Ogihara T, Fukunaka A et al (2013) The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

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The ER ligand complex binds to transcription factors such as AP-1 and Sp1 leading to gene activation