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Archived from the original on 6 October 2015

This selective binding initiates both genomic and non-genomic estrogenic responses that disrupt normal hormonal balance ( 3.1.2 Membrane receptor and calcium signaling dysregulation 3.1.2.1 Calcium homeostasis disruption EED exposure significantly disrupts intracellular calcium homeostasis, leading to aberrant Ca 2+ signaling patterns that compromise sperm function

During these processes, GSH is converted into its oxidized form, glutathione disulfide (GSSG)

Hydrolysis is generally acid- and/or base-catalyzed, which becomes evi-dent when pHrate profile is constructed

Deficiency, common in regions with selenium-poor soil, slashes GPx expression, particularly GPx1, leading to heightened oxidative stress

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