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The side chains of residues Glu256, Phe90, Val238 and Phe264 show tightly hydrophobic contacts and/or - interactions with the T1 molecule
Crosstalk between this integrin signaling complex and cadherins in AJs stabilizes cell-cell interactions
Tirzepatide does not prevent this metabolic adaptation entirely, but the degree of slowdown may be less than with diet-only weight loss
doi: 10.1073/pnas.2121987119 62 KamathDIwakumaTBossmannSH
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