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Protective effects of an ethanol extract of Angelica keiskei against acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells

Approximately 70% of circulating LDL is removed from the bloodstream through LDL receptor (LDLR)-mediated endocytosis in the liver, while the remaining LDL is taken up by extrahepatic tissues ( Figure 1C ) (11)

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Oxidative stress plays a central role in this melanocyte destruction, with elevated levels of ROS, such as HO, and deficiencies in key antioxidant enzymes creating a toxic environment for these cells

Nature 588 , 124129 (2020)