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The current consensus is that many factors may converge to cause the motor neuron damage typified by ALS (Rothstein 2009)

Retrieved 1 June 2014

Whereas, most psychiatric conditions vacillate within a single register between symptom exacerbation and various degrees of recovery, those attempting to fully understand bipolar disorder must contend with the fact that exacerbations come in two distinct flavors manias and depressions and that often these exacerbations can take any of a nearly infinite number of combinations of these two mood disturbances

It has been shown that certain medications at toxic doses such as paracetamol deplete glutathione

10.1016/j.canlet.2011.12.012 Cancer Lett

18 , who also reported behavioral disorders accompanying brain atrophy