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Excessively high iron ion levels within cells can lead to hydroxyl radical production via the Fenton reaction through interactions with hydrogen peroxide, thus promoting ROS production, lipid peroxidation, and the generation of oxidative byproducts such as MDA that are highly toxic, contributing to ferroptosis (Zeng et al., 2019)

Methionine Methionine is an essential amino acid that helps the body process and eliminate fat

Additionally, the heightened production of pro-inflammatory cytokines and chemokines from senescent cells exacerbates the inflammatory load and interferes with the aging process in CKD

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This process, called central sensitization, involves neuroinflammation, specifically activation of microglial cells in the brain and spinal cord

It plays a key role in skin clarity, immune function, and overall antioxidant defense