KEAP1-NRF2 system as a potential therapeutic target in ALS The presence in ALS of increased levels of OS markers and impaired antioxidant defense in the brain and peripheral tissues [25] together with the central role of NRF2 in inducing target genes to counteract OS [272] make the KEAP1-NRF2 system a suitable therapeutic target for drugs and small molecules
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5.1 Molecular mechanisms The mechanism of DPP-IV inhibition begins with the digestion of nutrient, primarily glucose and fat, which stimulates the release of incretin hormones from the gut [159]
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Difficulty walking When it is severe, a B12 deficiency can affect balance
