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Various performance metrics, including contour coefficient, dispersion, silhouette score, and sparsity, were calculated to determine the optimal rank value, ensuring clustering validity and stability ( Supplementary Figure 3 )

Faster onset, stronger local effect

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23 (IBM SPSS Statistic)

In vitro and in vivo , CD4 + CD25 + Foxp3 + Treg cells inhibited the activation, proliferation, and effector function of a wide range of immune cells, such as CD4 + and CD8 + T cells, natural killer (NK) cells, and NKT cells

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