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Use sterile handling, avoid vigorous shaking and repeated freeze-thaw cycles, and do not use the material if the seal is damaged or if persistent particles, unexpected cloudiness, or discoloration is present after dissolution

MoCA-OIS, MoCA Orientation Index Score, with more detail description included here

In another embodiment the otic formulation or composition comprises a particle formulation or composition wherein the sterility of the particle is ensured by sterile filtration of the precursor component solutions

P.DuvoisinR

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