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Multiple injection sites spread across the affected area may provide more complete coverage for extensive tendon involvement

Treatment doses typically range from 50 to 150 g daily of cyanocobalamin, preferably taken between meals, or 1,000 g daily for more rapid repletion, continued until deficiency is corrected

Oral-contraceptive interaction and immunogenicity backup or non-oral contraception for 4 weeks after initiation and each escalation

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