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However, the finding that mutation of a single aminoacid residue can drastically alter the substrate specificity and other characteristics (Bjrnestedt et al., 1995b

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Again, elevated levels of 8-OHdG have been linked to disease severity in various conditions, including cardiovascular disease (188), chronic periodontitis (189), Huntingtons disease (190), chronic kidney disease (191), and colorectal tumors (192194)