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Cephalalgia 38(1):1211

Additional to this pathway, there are other pathways that involve different adaptor proteins, but ultimately lead to the activation of NF- and other inflammatory signaling molecules, such as AP-1 (Yamamoto et al., 2002

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It's not dangerous, but it can: Add 13kg of scale weight (masking actual fat loss) Cause visible puffiness in legs or hands Be uncomfortable if severe What to do if you notice edema: Reduce KLOW dose by 50% and reassess after 2 weeks If on a daily frequency, drop to 3x/week If it persists, switch to pinning BPC-157 and GHK-Cu separately, leaving TB-500 out until the edema resolves Stay well-hydrated (counterintuitively, more water can help flush the retained fluid) Most people find edema resolves once the body adapts in weeks 24, or by reducing frequency

Nillson-Ehle et al 275 treated 28 patients for 6 weeks with L-carnitine 2 g IV after each dialysis session

doi:10.3390/nu10111564 [PubMed] 79