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Additionally, H&E and Safranin-O/Fast green staining showed that metformin treatment did not significantly ameliorate cartilage degradation induced by MIA-induced OA in Nrf2 KO mice (Fig

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This drives S-phase entry through upregulation of ribosome biogenesis genes and cyclin-dependent kinases, accelerating proliferation while fostering genomic instability (Qiu et al., 2022)

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Therefore, Trx may have a neuroprotective function in individuals suffering from acute ischemic stroke, and serum Trx levels are novel diagnostic and prognostic indicators that are also closely related to the severity of intracranial hemorrhage and long-term mortality

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