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Ipamorelin, a selective ghrelin receptor agonist, promotes GH release by inhibiting somatostatin and is noted for its minimal off-target endocrine effects, particularly on cortisol and prolactin

The antioxidant and detoxifying actions of glutathione contribute to its therapeutic effects, although it is important to note that oral bioavailability and absorption of glutathione can vary and may be influenced by individual factors

The results showed that the formulation was well-tolerated, with no significant changes noted in tear film break-up time (TBUT), ocular surface staining, or ocular surface disease index (OSDI) ratings between the two regimens and associated with improvements in patients with moderate DED [100]

Its secretion is pulsatile, meaning it occurs in intermittent bursts, with the largest surge typically happening shortly after falling asleep during slow-wave (deep) sleep