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(19) Researchers proposed this was due to the autoimmunity being stress-induced in the first place

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So Hydrolyzed Collagen is not really collagen, it is rather an undefined and varying mix of largish peptides

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Choi M, Schneeberger M, Fan W, Bugde A, Gautron L, Vale K, Hammer RE, Zhang Y, Friedman JM, Mangelsdorf DJ, Kliewer SA (2023) FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system

It is not a leakage enzyme and is released into normal circulation