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In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38

Caloric restriction Restricting the available calories to a model organism, such as a mouse or Caenorhabditis elegans , without undernourishing them

We will also order a thorough blood panel to assess key metabolic markers, including glucose levels, insulin sensitivity, thyroid function, and lipid profiles

18 GarcaI.Arenas-AlfonsecaL.MorenoI.GotorC.RomeroL

Vignal R, Crouzier D, Dabouis V, Debouzy JC

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