When mast cells are activated in response to progesterone, the resulting histamine surge helps explain many of the hallmark features of APD, including: Hives (urticaria) caused by histamine-induced blood vessel dilation Intense itching (pruritus) driven by histamine signaling in the skin Angioedema , or deeper swelling beneath the skin and mucous membranes Asthma-like symptoms or shortness of breath , due to histamines effects on airway smooth muscle This mast cellhistamine connection also clarifies why treatments that target allergic pathways are often effective in APD, even though progesterone is a hormone rather than a classic allergen
Aug 6 2014
One of its main roles is to neutralize free radicals, thus protecting cells from oxidative damage
10.1001/archpsyc.61.6.618 76 GobbiG.PulvirentiL
Mitrovi M, Stankovi Popovi V, Erceg S, Perii Mitrovi M, Dobrosavljevi A, Stupar A, Vukovi P, Zlatkovi D, Svorcan P
Volume tracking: The reconstitution volume sets the mcg per unit track it carefully so your total-blend dose stays accurate
