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Activated Caspase-3 cleaves gasdermin E (GSDME), releasing its N-terminal pore-forming domain (PFD) from the C-terminal inhibitory structure, thereby forming membrane pores and inducing GSDME-mediated pyroptosis (46)

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NDUFS4) and complex V (ATP synthase F1 subunit alpha

Am J Physiol Cell Physiol 281:C1495C1503 Lewerenz J, Maher P, Methner A (2011) Regulation of xCT expression and system x c function in neuronal cells