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More widespread use of available tools and development of new tools that discriminate between pore, leak, and unrestricted pathway permeabilities and underlying regulatory mechanisms will be essential to understanding the local and systemic consequences of intestinal barrier loss.

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10.1016/j.bbrc.2021.05.011 51 ThavarajahP.SeeC.-T.VandenbergA

It plays important roles in many cellular processes, including cell differentiation, proliferation, and apoptosis