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Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

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The identification of the elevation of the biochemical homocysteine as an independent risk factor for cardiovascular disease in men and women has focused additional attention on the methionine cycle (Aguilar)

These metabolic disturbances activate several pathogenic pathways that contribute to neuronal dysfunction and death, ultimately manifesting as DPN

Porter SN, Howarth GS, Butler RN