Consistent with the reprotoxic effects of excessive lipolysis, long-term exposure to HFD in mice results in increased lipid droplet accumulation within oocytes and cumulusoocyte complexes (COCs), reduced mitochondrial membrane potential, upregulated ER stress markers (ATF4, GRP78), and increased apoptosis in granulosa cells, culminating in decreased ovulation and fertilization rates (Wu et al., 2010)
Introduction With senior populations growing in many countries, stem cells attract more and more attention as a promising resource in anti-aging therapies
To convert the peak features into genes for interpretation of the signal, gene activities were inferred from the chromatin accessibility data using the function GeneActivity from Signac
10.1017/S0007114508939830 51 RiderS
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
Cell PhysiolBiochem