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Summary Both acute undernutrition and obesity in childhood have intersecting long-term outcomes including insulin resistance, type 2 diabetes, cardiovascular diseases, hepatic steatosis, cancers, and others, mediated through endocrine, immunological, epigenetic, and gut microbiome pathways, albeit via diverse specific mechanisms

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doi: 10.1053/j.gastro.2022.03.039 136 YokotaS.KonnoM.FujiwaraS.ToitaN.TakahashiM.YamamotoS.et al

Pheomelanin Associated with lighter pigmentation

-CAs often exhibit strongly pH-dependent activity in which an Asp is recruited into the open coordination site at high pH, thus abolishing turnover

The logic was soundpeptides are fragile protein chains, and the harsh, acidic environment of the stomach was seen as a catastrophic dead end