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Specifically, ATF-4 enhances stress resistance and promotes longevity in worms by upregulating the transsulfuration enzyme CTH-2, increasing hydrogen sulfide (H 2 S) production (Statzer et al., 2022)

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While the left ovaries were flash-frozen and stored at -80 C until they were utilized for biochemical and molecular research, the right ovaries were fixed in 10% buffered formalin for histopathological and immunohistochemical analyses

doi: 10.24326/asphc.2020.4.4 119 JarvisD