Frequently Asked Questions How soon after gastric sleeve surgery can B12 deficiency develop
Some historical or research protocols have used much higher doses (e.g., 250 mg/kg as a single IV bolus in diagnostic growth-hormone testing), but such regimens are uncommon outside controlled studies.Dose escalation should proceed cautiously, with monitoring of vital signs, electrolytes, and-if relevant-ammonia levels
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18 A study in 2003 compared oral versus sublingual cyano-B12 (500 g per day for 8 weeks), and found that both increased B12 levels significantly without a significant difference between the two
This is due to the inhibition of DNA synthesis (specifically purines and thymidine)