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[DOI] [PMC free article] [PubMed] [Google Scholar] Nash A, Notou M, Lopez-Clavijo AF, Bozec L, de Leeuw NH, Birch HL (2019) Glucosepane is associated with changes to structural and physical properties of collagen fibrils

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"I'd say maybe only a handful of people at most in the last 10 years have I ever actually thought would benefit from B12 injections." As to why some physicians would be needlessly prescribing B12 shots, he said, "It may be just habit

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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

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