Increases in GGT levels, therefore, are an indicator of an increased demand for glutathione synthesis, likely due to xenobiotic exposure, an association which appears to be well-supported
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M.HorcajadaJ
These authors verified that creatine, at doses similar to those detected in plasma after supplementation, had an antioxidant cytoprotective activity on three cell lines against three different oxidative agents: H 2 O 2 , OONO and tert -butylhydroperoxide (tB-OOH)
Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards
In the GSH redox cycle, antioxidant enzymes also play a significant role in maintaining the oxidative balance in the cell