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Interestingly, zinc imbalance has been linked to the hypermethylation and silencing of zinc transporters such as ZIP8 and ZIP13, suggesting a feedback loop between zinc status, transporter expression and nuclear epigenetic regulation 116,117

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The primary purpose of this visit was to assess compliance and record adverse events

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By summarizing data from the animal literature, we conclude the mechanisms of curcumin for chronic diseases combined with anxiety/depressive are mainly focused on the following aspects: (1) Anti-inflammatory and antioxidant effects: for diabetes, obesity or pain, curcumin can reduce pro-inflammatory cytokines (TNF-, IL-6) and regulate pathways such as NF-B

Nat Neurosci 4 : 10861092