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However, research into transdermal patches combined with penetration enhancers or microneedle arrays is exploring whether sustained peripheral delivery can achieve sufficient systemic levels to produce CNS effects for highly potent compounds

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While the use of conventional and targeted therapies has improved patient outcomes, there have been reported complications due to the nephrotoxic effects of these anti-cancer drugs

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The mitogen-activated protein kinase (MAPK) signaling pathway is also involved in regulating cell growth, differentiation, and apoptosis [133]