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Methylenetetrahydrofolate reductase ( MTHFR ) and Glutathione S-transferase omega-1( GSTO-1 ) are two genes that are key participants in the metabolic pathways regulating oxidative stress in the brain (Fig 1)

Together, they enhance skin elasticity and work harmoniously to reduce the appearance of stretch marks

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While this potential benefit is being investigated, it should not be considered a primary reason for using these medications, which are specifically FDA-indicated for weight management and/or glycemic control in appropriate patients

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Repeated activation of the receptors can lead to upregulation and sensitization, causing hyperexcitability of the receptor even at low levels