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A practical heuristic: if youre set on using a modified form, the more conservative middle-ground protocols (1 mg/day for 20 days for N-acetyl amidate, or 1-2 mg for amidate alone) sit closer to the dose math that would be theoretically equivalent to the base epithalon protocols if the modifications deliver something like 5-10x bioavailability improvement

Moreover, in patients with either diffuse or atypical CHI, SST was found to be highly co-expressed with NKX2.2, which is a marker of prenatal immature cells, indicating functional abnormality of these cells 35,36

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