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A deeper understanding of the mechanisms of action of small molecules, the exact sites of action, the necessary dose to achieve the desired effect, and the optimal time to start antioxidant therapy for preventive or curative effects may provide a rational approach that may result in greater pharmacological and clinical success in low-molecular-weight antioxidant therapy

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However, despite the upregulation of SOD2, its ability to fully mitigate ROS appears limited, as ROS levels remain significantly higher in ectopic endometrial tissue compared with in eutopic tissue (37)