There are specific conditions that are necessary for these conformational changes to occur such as acidic pH, enzymatic actions, etc
Eur J Gastroenterol Hepatol (2021) 32:28893
Lancet 389 (10086), 23282337
It was reported to lead to a nearly 50% reduction in weight gain in obese mice noticed over three weeks
The causes of desire loss Lack of quality sleep, high stress, poor diet, poor physical health, medications and birth control pills, low physical activity, unresolved conflicts, repressed emotions, depression, and anxiety, past sexual abuse, poor self-image and lack of self-confidence, infidelity, and menopause (or other hormonal imbalances like low thyroid) are the main psychological and emotional causes of low sex drive in men and women
doi: 10.1016/j.jconrel.2013.05.037