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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

When you inhibit NNMT, your cells can make more NAD+, a molecule that powers your mitochondrial energy factories

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Initially, research focused on its cytoprotective abilitiesmeaning its capacity to protect cells from harm

By speeding up muscle repair and reducing downtime between workouts, it allows for greater training volume, which is a key driver of muscle growth