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PD involves biochemical changes that worsen neuronal degeneration, including -synuclein accumulation, dopaminergic neuron loss, and basal ganglia disruption

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Importantly, persistent activation of NRF2 that is induced pharmacologically in KEAP1-NRF2-intact cancer cells also decreases NEAA synthesis and makes them rely on exogenous NEAAs (LeBoeuf et al

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Thats because age and chronic illness affect the functional integrity of cell membranes, which has a major impact on the vascular and neurological systems

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