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Both metformin and the PPI (omeprazole) can contribute to B12 deficiency

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Lack of absorption and genetic factors may also contribute to vitamin B12 deficiency

We suggest doing blood tests and B12 level checks often

A standard B12 injection focuses on vitamin B12

That gap is worth planning around: the beyond-use window of a reconstituted solution (covered in the storage section) can be shorter than the drug supply lasts, especially for the 10 mg vial, so re-order and reconstitution-volume decisions should be made against the shorter of the two limits the stability window or the drug supply not just the drug supply alone